WebRBM10 has long been considered a tumor suppressor because it promotes apoptosis through the regulation of the MDM2-p53 negative feedback loop, Bcl-2, Bax, and other apoptotic proteins and inhibits proliferation through the Notch signaling and rap1a/Akt/CREB pathways. However, it has been recently demonstrated that RBM10 can also promote … WebApr 12, 2024 · p53 loss increases the frequency and drug resistance of multiple myeloma tumor-initiating cells. Increased Notch signaling and ID1 expression enhance the …
Simultaneous overexpression of miR-126 and miR-34a induces a …
Web10 hours ago · Evidence was also provided that Notch-1 was the target of miR-137 and that Notch downregulation resulted in impaired cell proliferation. Notch-1 is a transmembrane protein with different biological roles, including the regulation of the interactions between physically adjacent cells. ... Notably, TGF-β1 can improve p53 expression, triggering ... WebNov 29, 2024 · Among them, the p53 mutation is found in ~60% of colorectal cancers, and a majority of mutations are missense-type at ‘hot spots’, suggesting an oncogenic role of mutant p53 by ‘gain-of-function’ mechanisms. fareham health centre osborn road
Contribution of p53 in sensitivity to EGFR tyrosine kinase ... - Nature
WebSep 1, 2024 · Notch INSM1 p53 Diagnostic marker Introduction Pancreatic neuroendocrine tumors (PanNETs) comprise a heterogeneous group of endocrine tumors arising in the pancreas [1, 2 ]. Studies of Asian and European populations show that these are uncommon neoplasms, with an incidence lower than 1 per 100,000 persons per year 2, 3, 4. WebDec 15, 2024 · Since the discovery of the first MDM2 inhibitors, we have gained deeper insights into the cellular roles of MDM2 and p53. In this review, we focus on MDM2 inhibitors that bind to the p53-binding domain of MDM2 and aim to disrupt the binding of MDM2 to p53. We describe the basic mechanism of action of these MDM2 inhibitors, such as nutlin … WebMay 1, 2015 · Quantitative ChIP analysis of Notch-1, p53 and MAML1 at the HEY1 promoter. A: MCF-7 cells were transfected as indicated at the bottom with p53 vector, p53 alone, WT MAML1 alone, p53 plus WT MAML1 ... fareham hearing centre