Ferritinophagy cargo receptor ncoa4

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August undefined, 2024

WebSep 5, 2024 · Using a genome-wide CRISPR screening approach in parental H4 cells (top), TAX1BP1 was identified as a functional binding partner for NCOA4 and found to regulate ferritinophagy independently of its role as a selective autophagy cargo receptor (1). WebApr 12, 2024 · NCOA4 is a selective cargo receptor in ferritinophagy. NCOA4 finely regulates cellular iron homeostasis by anticipating the autophagic degradation of ferritin. Under iron-replete cellular conditions, HERC2-mediated ubiquitylation facilitates the …

Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy

WebMay 21, 2024 · Nuclear receptor coactivator 4 (NCOA4) is the selective cargo receptor that can bind ferritin and deliver it to autophagosome, leading to the selective autophagy of ferritin, ... Although the NCOA4-mediated ferritinophagy plays a positive role in the proliferating DPSCs, the potential detrimental effect of ferritinophagy in MSCs-based ... WebNCOA4 was identified as a key player in ferritinophagy, serving as an autophagic cargo receptor to facilitate the delivery of ferritin for lysosomal degradation (Mancias et al., … proforce 2500 watt generator

Ferritinophagy in the etiopathogenic mechanism of

WebNCOA4 Mediates Ferritinophagy and Regulates Intracellular Bioavailable Iron. We recently identified NCOA4 as the selective autophagy receptor mediating delivery of iron-laden ferritin to the lysosome for degradation … WebOct 23, 2024 · Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin, the cytosolic iron storage complex, in a … WebMar 24, 2024 · When free iron levels are high, iron is stored as Fe 3+ in ferritin, which can undergo ferritinophagy, i.e., autophagic degradation of ferritin via nuclear receptor coactivator 4 (NCOA4, a cargo-binding protein), which releases iron into the cytosol as Fe 2+ and contributes to the LIP. HERC2 is an E3 ubiquitin ligase for NCOA4 that promotes … remote speed monitor

Nuclear receptor coactivator 4-mediated ferritinophagy drives ...

NCOA4: More than a receptor for ferritinophagy Journal …

WebAug 12, 2016 · Using NCOA4 as the cargo receptor, ferritinophagy recognizes ferritin and delivers it for lysosomal degradation, leading to … Web1 day ago · Based on the above studies, Asano et al. [32] hypothesized that the selective autophagic process of ferritinophagy is likely to rely on a cargo receptor that was later identified as NCOA4. Mancias et al. first proposed the concept of ferritinophagy and later used quantitative proteomics to identify NCOA4 as the receptor for this selective ... remote speaker switchWebFeb 1, 2024 · NCOA4 deficiency abolished ferritinophagy increasing ferritin level and making the cells more resistant to erastin, but unexpectedly more sensitive to RSL3. Interestingly, we found that erastin promoted ferritinophagy in HeLa cells expressing NCOA4, increasing the free iron, lipid peroxidation and the sensitivity to ferroptosis. proforce 3000 watt generator

"WebOct 5, 2015 · NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical for regulation of intracellular iron bioavailability. However, how ferritinophagy flux is controlled and the roles of NCOA4 in iron-dependent processes are poorly understood. " - Ferritinophagy cargo receptor ncoa4

Ferritinophagy cargo receptor ncoa4

The Role of NCOA4-Mediated Ferritinophagy in …

WebOct 1, 2024 · Nuclear receptor coactivator 4 (NCOA4) is identified as a cargo receptor for the autophagic degradation of ferritin that is known as ferritinophagy, and NCOA4 … WebApr 11, 2024 · Introduction. Ferroptosis is a non-apoptotic, iron-dependent form of cell death characterized by the accumulation of lipid peroxides. Citation 1 Its foundation is active iron, which can be produced through the ferritinophagy pathway. Citation 2 Ferritinophagy is a new type of autophagy that relies on the nuclear receptor coactivator 4 (NCOA4), a …

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WebOct 5, 2015 · NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical for regulation of intracellular iron bioavailability. However, how ferritinophagy flux is controlled and the …

Web1 day ago · Based on the above studies, Asano et al. [32] hypothesized that the selective autophagic process of ferritinophagy is likely to rely on a cargo receptor that was later … WebOct 14, 2024 · Mechanistically, autophagy receptor SQSTM1/p62 acts as a platform to promote the interaction between NCOA4 and LC3, thus promoting ferritin degradation to enhance ferroptosis sensitivity, this process is regulated by USP8 . The suppression of USP8-SQSTM1-NCOA4-ferritin axis through up-regulating ferritinophagy and …

WebApr 28, 2024 · Ferritinophagy is the lysosome degradation of ferritin, targeted by the NCOA4 (Nuclear Receptor Coactivator 4) chaperone. DDIT4 is a potent inhibitor of mTOR, acting downstream of AKT by... WebApr 11, 2024 · Introduction. Ferroptosis is a non-apoptotic, iron-dependent form of cell death characterized by the accumulation of lipid peroxides. 1 Its foundation is active iron, which can be produced through the ferritinophagy pathway. 2 Ferritinophagy is a new type of autophagy that relies on the nuclear receptor coactivator 4 (NCOA4), a receptor that …

WebApr 3, 2024 · NCOA4 is a selective cargo receptor that mediates the autophagic degradation of iron proteins in the cytoplasmic iron storage complex (Mancias et al. …

WebSep 8, 2024 · Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin (“ferritinophagy”), the cytosolic iron storage complex. NCOA4-mediated … remote speedy hatWebFeb 23, 2024 · The cytoplasm-to-vacuole targeting (Cvt) pathway is a biosynthetic autophagy-related process specific to yeast, in which vacuolar enzymes are transported from the cytoplasm into the vacuole... proforce backpackWebNov 23, 2024 · The ferritin-specific autophagy is called ferritinophagy, wherein a cargo receptor called nuclear receptor coactivator 4 (NCOA4) binds ferritin heavy chain and directs ferritin to the isolation membrane. 20, 21 The iron metabolism in SENDA/BPAN evaluated in previous studies was insufficient and inconclusive, as the analyses did not … proforce 1200xp troubleshootingWebSep 8, 2024 · Ferritinophagy is a type of autophagy mediated by nuclear receptor activator 4 (NCOA4), which plays a role in inducing ferroptosis by regulating iron homeostasis and producing reactive oxygen ... proforce 23 paint sprayer priceWebDec 15, 2024 · Ferroptosis inhibitors, such as ferrostatin-1, have been applied as potential drug candidates for COVID-19. Notably, NCOA4 has been reported to be the cargo … remote speed boatWebOct 14, 2024 · Mechanistically, autophagy receptor SQSTM1/p62 acts as a platform to promote the interaction between NCOA4 and LC3, thus promoting ferritin degradation to … proforce 3125 watt generatorWebFigure 6 Restoring iron homeostasis via NCOA4-mediated ferritinophagy reverse growth suppression role of PINK1 loss. A. shNT and shPINK1 cells were treated with 100 μM Ferric ammonium citrate (FAC) and proliferation was measured for 72 hours. B. ... Ferritinophagy is coordinated by the cargo receptor NCOA4, which binds to both FTL and FTH1 and ... proforce antibacterial soap