Faah knockout mice
WebSee Taconic Bioscience’s Constitutive Knock Out mouse, model # Faah. Toggle navigation. ... For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as … WebApr 4, 2024 · alpha-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression. ... (CB1R) and fatty acid amide hydrolase (FAAH) knock out mice. Data show that systemic, hippocampal, and peripheral blockade of cannabinoid type-1 (CB1) receptors abolished the stress-induced …
Faah knockout mice
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WebCD1 mice lacking the CB 1 receptors ('knockout' [KO] mutants) were compared with wildtype (WT) littermates for their ability to degrade AEA through an AEA membrane transporter (AMT) and an AEA hydrolase (fatty acid amide hydrolase, FAAH). The age dependence of AMT and FAAH activity were investigated in 1- or 4-month-old WT and … WebJZL184 also partially substituted in AEA-trained FAAH (−/−) mice in the water maze procedure, which may suggest incomplete overlap in the stimulus effects of AEA and JZL184. Further research is needed to confirm these hypotheses. Finally, through the use of a novel water maze cannabinoid discrimination procedure that requires minimal ...
WebApr 1, 2024 · Male wild-type C57BL6 (WT) and Faah−/− mice were administered a single dose of intraperitoneal injection of cisplatin (30 mg/kg) and euthanatized 72 hours later. Faah−/− mice showed a reduction of cisplatin-induced blood urea nitrogen, plasma creatinine levels, kidney injury markers, and tubular damage in comparison with WT mice. WebMoreover, as revealed by additional behavioural analysis, CB1-KO mice exhibit a decreased sensitivity to the rewarding properties of sucrose. In agreement with this finding, the differences between WT and CB1-KO mice faded away when the palatability of sucrose was devaluated by adding quinine, but not when a non-caloric sweetener, saccharin ...
WebWe investigated the formation of PGF 2α 1-ethanolamide, PGE 2 1-ethanolamide, and PGD 2 1-ethanolamide (prostamides F 2α, E 2, and D 2, respectively) in liver, lung, kidney, … WebJun 29, 2024 · Similar to FAAH KO mice, PF-3845-pretreated mice displayed a moderate enhancement of the effect of low-dose nicotine on NAc 5-HT release (p < 0.01). These observations in mice suggest that enhanced nicotine-induced NAc DA release might contribute to increased sensitivity to the conditioned rewarding effects of low-dose …
WebDec 22, 2009 · FAAH knockout mice were generated by intercrossing 129SvJ-C57BL/6 FAAH heterozygous mice, and backcrossed into the C57BL/6 for at least five …
WebWe investigated the formation of PGF 2α 1-ethanolamide, PGE 2 1-ethanolamide, and PGD 2 1-ethanolamide (prostamides F 2α, E 2, and D 2, respectively) in liver, lung, kidney, and small intestine after a single intravenous bolus administration of 50 mg/kg of anandamide to normal and fatty acid amide hydrolase knockout (FAAH −/−) male mice.One group of … meaning of motherlyWebDec 22, 2009 · FAAH knockout mice were generated by intercrossing 129SvJ-C57BL/6 FAAH heterozygous mice, and backcrossed into the C57BL/6 for at least five generations. 20 FAAH −/− mice and their wild-type ... pectine wikipediaWebAug 1, 2024 · AEA has roles in nociception, fear-extinction memory, anxiety, and depression. 3, 4 FAAH knockout mice have elevated brain concentrations of AEA, display an analgesic phenotype in response to acute thermal stimuli, and show reduced pain in formalin and carrageenan inflammatory models. 5, 6 FAAH is therefore an attractive … pectine phWebJul 26, 2012 · Fatty acid amide hydrolase (FAAH) knockout mice are prone to excess energy storage and adiposity, whereas mutations in FAAH are associated with obesity in humans. However, the molecular mechanism by which FAAH affects energy expenditure (EE) remains unknown. meaning of moths symbolismWebGenetic Knockout of Fatty Acid Amide Hydrolase (FAAH) Ameliorates Cisplatin-induced Nephropathy in Mice ... participates in different kidney diseases. Inhibition of fatty acid … meaning of motif in danceWebApr 9, 2024 · Furthermore, Faah-knockout mice display high levels of N-acylethanolamines . The lack of Faah promotes the development of obesity as Faah-deficient mice fed with regular diet have higher body weight . Faah-deficiency is associated with increased lipid storage and decreased insulin sensitivity [156,157]. pectineo-femoral pinch syndromeWebDec 17, 2024 · For example, Faah knockout mice had greater body weight, fat mass, and triglyceride levels compared to wildtype mice, under both a standard and high-fat diet [31,32]. It is important to note that there are many substrates of FAAH other than AEA (many of which do not act at CB receptors) and that the functions of FAAH substrates … meaning of motif in hindi